Comparative antihypertensive effects of angiotensin II receptor antagonists

Détails

ID Serval
serval:BIB_A61BD40697EB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Comparative antihypertensive effects of angiotensin II receptor antagonists
Périodique
Journal of the American Society of Nephrology
Auteur(s)
Burnier  M., Brunner  H. R.
ISSN
1046-6673 (Print)
Statut éditorial
Publié
Date de publication
04/1999
Volume
10 Suppl 12
Pages
S278-82
Notes
Comparative Study
Journal Article
Review --- Old month value: Apr
Résumé
Blockade of the renin-angiotensin system is recognized as an effective approach for the treatment of hypertension and congestive heart failure. It is possible to antagonize the effects of angiotensin II (AngII) by blocking its receptors, using nonpeptide receptor antagonists. Six angiotensin receptor blockers (ARB) have been approved for the treatment of hypertension: losartan, valsartan, irbesartan, candesartan, telmisartan, and eprosartan. These new drugs are highly selective for the AT1 receptor subtype and induce dose-dependent inhibition of the BP response to exogenous AngII. Numerous double-blind, placebo-controlled studies have demonstrated that ARB are efficacious for treating mild, moderate, and severe hypertension. When compared with other classes of antihypertensive agents, ARB are as effective as angiotensin-converting enzyme inhibitors, calcium antagonists, thiazide diuretics, and beta-blockers. One advantage of ARB as a class is their excellent tolerability and side effect profile. Several large clinical trials of ARB are now under way to demonstrate their benefits in hypertension, heart failure, and type II diabetic nephropathy.
Mots-clé
*Angiotensin II Antihypertensive Agents/*pharmacology Dose-Response Relationship, Drug Heart Failure, Congestive/drug therapy Humans Hypertension/*drug therapy Receptors, Angiotensin/*antagonists & inhibitors
Pubmed
Web of science
Création de la notice
25/01/2008 13:56
Dernière modification de la notice
20/08/2019 16:11
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