Blunted vasodilatory responses in the cutaneous microcirculation of cigarette smokers

Détails

ID Serval
serval:BIB_A614BF98E8BD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Blunted vasodilatory responses in the cutaneous microcirculation of cigarette smokers
Périodique
American Heart Journal
Auteur⸱e⸱s
Pellaton  C., Kubli  S., Feihl  F., Waeber  B.
ISSN
1097-6744 (Electronic)
Statut éditorial
Publié
Date de publication
08/2002
Volume
144
Numéro
2
Pages
269-74
Notes
Clinical Trial
Journal Article --- Old month value: Aug
Résumé
OBJECTIVE: The present study was undertaken to investigate whether chronic smoking alters the vasodilatory capacity in the microcirculation. METHODS: We assessed, in habitual cigarette smokers, the forearm skin blood flow response to iontophoretically applied acetylcholine (endothelium-dependent vasodilator) and sodium nitroprusside. Postocclusive forearm reactive hyperemia was also explored. The skin blood flow responses were determined with a laser-Doppler flowmeter that allowed us to scan the surface after acetylcholine and sodium nitroprusside application. RESULTS: Forty healthy male volunteers were included. Twenty subjects were aged 20 to 35 years and 20 subjects were aged 40 to 60 years. We studied the following 4 groups of 10 subjects each: group 1, younger smokers (mean of 7.2 pack-years); group 2, older smokers (mean of 30 pack-years); group 3, younger nonsmokers; and group 4, older nonsmokers. On the day of the experiment, the subjects of groups 1 and 2 were asked to smoke at least 15 cigarettes from the morning until the afternoon, when the experiments were performed. No significant difference in the studied parameters was observed between younger smokers and younger nonsmokers. In older smokers, however, both acetylcholine- and sodium nitroprusside-induced skin blood flow increases were significantly attenuated in comparison with nonsmokers. Heart rate also was significantly blunted by long-term cigarette smoking in older subjects. CONCLUSION: These data show that the vasodilatory response of the skin microvasculature is impaired in subjects who have smoked cigarettes for many years. This abnormality involves both endothelium-dependent and endothelium-independent responses.
Mots-clé
Adult Brachial Artery/physiopathology Constriction, Pathologic/physiopathology Forearm Hemodynamic Processes Humans Hyperemia/physiopathology Iontophoresis Laser-Doppler Flowmetry Male Microcirculation Middle Aged Regional Blood Flow Skin/*blood supply Smoking/*physiopathology *Vasodilation
Pubmed
Web of science
Création de la notice
25/01/2008 9:37
Dernière modification de la notice
20/08/2019 15:11
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