Long-term survival after concomitant chemoradiotherapy prior to surgery in advanced cervical carcinoma.

Détails

ID Serval
serval:BIB_A5B42E3267C9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Long-term survival after concomitant chemoradiotherapy prior to surgery in advanced cervical carcinoma.
Périodique
Gynecologic oncology
Auteur(s)
Houvenaeghel G., Lelievre L., Gonzague-Casabianca L., Buttarelli M., Moutardier V., Goncalves A., Resbeut M.
ISSN
0090-8258 (Print)
ISSN-L
0090-8258
Statut éditorial
Publié
Date de publication
02/2006
Peer-reviewed
Oui
Volume
100
Numéro
2
Pages
338-343
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To report the long-term survival of 35 patients who underwent surgery after concomitant chemoradiation for locally advanced cervical cancers.
From 1988 to 1992, 20 bulky IB-IIB patients and 15 stage III-IVA patients underwent surgery after concurrent chemotherapy (CDDP and 5-FU) and radiotherapy. 26 had a hysterectomy, 8 had an exenteration, 1 had no tumor resection. 21 had a para-aortic lymphadenectomy. Endpoints were recurrence and distant metastasis rates, overall survival (OS) and disease-free survival (DFS) at 5 and 10 years. Analysis included FIGO stage, type of surgery (palliative or curative), response to chemoradiation or para-aortic lymphatic status.
Surgery had been only palliative in 6 cases (17.1%). A pelvic control has been achieved in 31 patients (88.6%). Pelvic recurrences occurred after a median interval of 7 months. Distant metastases occurred in 10 patients (28.6%), after a median interval of 20 months. So far, 16 patients have died (45.7%). The 10-year DFS is 56.7% in the whole series. Only the type of surgery significantly affected the OS. Only the para-aortic lymphatic status significantly affected the DFS.
Associating chemoradiation with curative surgery, we obtained a 10-year DFS of 66.4% (OS 57.7%). Adjuvant surgery may increase the survival as it reduces the risk of local relapse.
Mots-clé
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Cisplatin/administration & dosage, Combined Modality Therapy, Disease-Free Survival, Female, Fluorouracil/administration & dosage, Humans, Hysterectomy, Lymphatic Metastasis, Middle Aged, Neoplasm Metastasis, Neoplasm Staging, Pelvic Exenteration, Treatment Outcome, Uterine Cervical Neoplasms/pathology, Uterine Cervical Neoplasms/therapy
Pubmed
Web of science
Création de la notice
31/10/2019 18:20
Dernière modification de la notice
05/02/2021 7:26
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