Simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in human hair by gas chromatography-mass spectrometry.

Détails

ID Serval
serval:BIB_A58CCF8B8AD1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in human hair by gas chromatography-mass spectrometry.
Périodique
Journal of Chromatography. B, Biomedical Applications
Auteur(s)
Kintz P., Cirimele V., Tracqui A., Mangin P.
ISSN
1572-6495[print], 1572-6495[linking]
Statut éditorial
Publié
Date de publication
1995
Volume
670
Numéro
1
Pages
162-166
Langue
anglais
Résumé
A procedure is presented for the simultaneous identification and quantification of amphetamine (AP), methamphetamine (MA), methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) in human hair. The method involves decontamination of hair with dichloromethane and warm water, heat-alkaline hydrolysis in the presence of deuterated internal standards, liquid-liquid extraction and gas chromatography-mass spectrometry after derivatization with pentafluoropropionic anhydride-pentafluoropropanol. The limit of detection for AP, MA and MDA was 0.05 ng/mg using a 50-mg hair sample; for MDMA it was 0.1 ng/mg. Coefficients of variation ranged from 7 to 18%. This assay has been successfully utilized in the evaluation of the deposition of the drugs in hair obtained from various parts of the anatomy of a stimulant abuser.
Mots-clé
3,4-Methylenedioxyamphetamine/analysis, Amphetamine/analysis, Gas Chromatography-Mass Spectrometry/methods, Hair/chemistry, Humans, Methamphetamine/analysis, N-Methyl-3,4-methylenedioxyamphetamine/analysis, Reproducibility of Results, Substance-Related Disorders/diagnosis
Pubmed
Création de la notice
19/10/2010 15:30
Dernière modification de la notice
20/08/2019 15:10
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