Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies.

Détails

ID Serval
serval:BIB_A52BFAD7DA3C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies.
Périodique
Clinical cancer research
Auteur(s)
Quail D.F., Joyce J.A.
ISSN
1078-0432 (Print)
ISSN-L
1078-0432
Statut éditorial
Publié
Date de publication
15/02/2017
Peer-reviewed
Oui
Volume
23
Numéro
4
Pages
876-884
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Tumor-associated macrophages (TAMs) are a major cellular component of numerous tumor types. TAM-targeted therapies include depletion strategies, inhibiting their effector functions or reprogramming toward an antitumorigenic phenotype, with varying degrees of efficacy. Here, we review preclinical and clinical strategies to target macrophages in cancer and discuss potential explanations for why some strategies are effective while other approaches have shown limited success. javax.xml.bind.JAXBElement@74e333c7 .

Mots-clé
Humans, Macrophages/drug effects, Macrophages/pathology, Molecular Targeted Therapy, Neoplasms/drug therapy, Neoplasms/genetics, Neoplasms/pathology, Receptor, Macrophage Colony-Stimulating Factor/antagonists & inhibitors, Receptor, Macrophage Colony-Stimulating Factor/genetics, Tumor Microenvironment/drug effects, Tumor Microenvironment/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/12/2016 18:29
Dernière modification de la notice
20/08/2019 15:10
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