Increase of circulating neutrophil and platelet microparticles during acute vasculitis and hemodialysis

Détails

ID Serval
serval:BIB_A4CD8B6D7DAC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Increase of circulating neutrophil and platelet microparticles during acute vasculitis and hemodialysis
Périodique
Kidney Int
Auteur⸱e⸱s
Daniel L., Fakhouri F., Joly D., Mouthon L., Nusbaum P., Grunfeld J. P., Schifferli J., Guillevin L., Lesavre P., Halbwachs-Mecarelli L.
ISSN
0085-2538 (Print)
ISSN-L
0085-2538
Statut éditorial
Publié
Date de publication
04/2006
Volume
69
Numéro
8
Pages
1416-23
Langue
anglais
Notes
Daniel, L
Fakhouri, F
Joly, D
Mouthon, L
Nusbaum, P
Grunfeld, J-P
Schifferli, J
Guillevin, L
Lesavre, P
Halbwachs-Mecarelli, L
eng
Comparative Study
Research Support, Non-U.S. Gov't
Kidney Int. 2006 Apr;69(8):1416-23. doi: 10.1038/sj.ki.5000306.
Résumé
Release of microparticles (MPs) from blood cells may occur upon various activation signals. MPs from neutrophil and platelet have been studied in systemic infectious diseases and cardiovascular diseases, respectively. They are here investigated in common nephropathies including vasculitis and dialysis, two conditions characterized by neutrophil activation. Flow cytometry analysis of neutrophil-derived (CD66b-positive) and platelet-derived (CD41a-positive) MPs was performed on 213 plasma samples from patients with various nephropathies, including 46 patients with vasculitis and 40 hemodialysis patients. MPs released ex vivo, during neutrophil activation in whole blood, were also measured in these patients. Correlations with clinical parameters and creatinine clearance were evaluated. The results show that MPs present in plasma from patients or healthy controls are from various origins: platelet-derived (38+/-22%), neutrophil-derived (2.8+/-3.8%) MPs, mixed aggregates of neutrophil/platelet MPs (28+/-15%) or neither from neutrophil or platelet (null) 31+/-20%. Acute vasculitis showed the highest level of all types of MPs, while other nephropathies did not result in significant changes of MP levels. A significant increase was observed during hemodialysis sessions. In patients with renal failure, no correlation was seen between MP levels and creatinine clearance. In conclusion, neutrophil and platelet MP levels are non-specific markers of neutrophil activation during vasculitis acute phase and dialysis-induced inflammation. Circulating aggregates of neutrophil/platelet MPs co-express adhesion molecules of both cell types and may be thus endowed with inflammation and coagulation- thus modulating properties.
Mots-clé
Acute Disease, Adolescent, Adult, Aged, Aged, 80 and over, Antigens, CD/analysis, Blood Platelets/*metabolism, Case-Control Studies, Cell Adhesion Molecules/analysis, Cell Aggregation, Female, Flow Cytometry, GPI-Linked Proteins, Humans, Male, Middle Aged, Neutrophil Activation, Neutrophils/*metabolism, Particle Size, Platelet Membrane Glycoprotein IIb/analysis, Renal Dialysis/*adverse effects, Vasculitis/*metabolism/physiopathology
Pubmed
Création de la notice
01/03/2022 11:18
Dernière modification de la notice
02/03/2022 7:36
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