Circulating non-coding RNAs as a diagnostic and management biomarker for breast cancer: current insights.

Détails

ID Serval
serval:BIB_A4CD22B56272
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Circulating non-coding RNAs as a diagnostic and management biomarker for breast cancer: current insights.
Périodique
Molecular biology reports
Auteur⸱e⸱s
Hosseinalizadeh H., Mahmoodpour M., Ebrahimi A.
ISSN
1573-4978 (Electronic)
ISSN-L
0301-4851
Statut éditorial
Publié
Date de publication
01/2022
Peer-reviewed
Oui
Volume
49
Numéro
1
Pages
705-715
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Cancer biomarkers can be used to determine the molecular status of a tumor or its metastases, which either release them directly into body fluids or indirectly through disruption of tumor/metastatic tissue. New minimally invasive and repeatable sample collection methods, such as liquid biopsy, have been developed in the last decade to apply cancer knowledge and track its progression. Circulating non-coding RNAs, which include microRNAs, long non-coding RNAs, and PIWI-interacting RNAs, are increasingly being recognized as potential cancer biomarkers. The growing understanding of cancer's molecular pathogenesis, combined with the rapid development of new molecular techniques, encourages the study of early molecular alterations associated with cancer development in body fluids. Specific genetic and epigenetic changes in circulating free RNA (cf-RNA) in plasma, serum, and urine could be used as diagnostic biomarkers for a variety of cancers. Only a subset of these cf-RNAs have been studied in breast cancer, with the most extensive research focusing on cf-miRNA in plasma. These findings pave the way for immediate use of selected cf-RNAs as biomarkers in breast cancer liquid biopsy, as well as additional research into other cf-RNAs to advance.
Mots-clé
Biomarkers, Tumor/blood, Biomarkers, Tumor/genetics, Breast Neoplasms/blood, Breast Neoplasms/diagnosis, Breast Neoplasms/genetics, Carcinogenesis/genetics, Circulating MicroRNA/blood, Circulating MicroRNA/genetics, Epigenesis, Genetic, Female, Humans, Liquid Biopsy/methods, Mutation, RNA, Long Noncoding/blood, RNA, Long Noncoding/genetics, RNA, Small Interfering/blood, RNA, Small Interfering/genetics, Biomarker, Breast cancer, Cancer diagnosis, Liquide biopsy, Non-coding RNA
Pubmed
Web of science
Création de la notice
08/11/2021 9:52
Dernière modification de la notice
29/03/2022 5:36
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