Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites.

Détails

ID Serval
serval:BIB_A4A0594F9502
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites.
Périodique
Trends in immunology
Auteur⸱e⸱s
Canny G., Levy O.
ISSN
1471-4906
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
29
Numéro
11
Pages
541-7
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
At mucosal surfaces, we must co-exist with a high density of diverse microorganisms; therefore, protection against these occurs on multiple levels. Leukocyte- and epithelial derived-antimicrobial peptides and proteins (AMPs) comprise an essential component of immune defense. These molecules possess antibacterial, antifungal and signalling properties and probably contribute to defence and maintenance of homeostasis between the host and commensal microorganisms. Among these AMPs is bactericidal/permeability-increasing protein (BPI), an antimicrobial protein with potent endotoxin-neutralising activity, and several homologs. This review explores the roles of BPI and and its homologs at the mucosal interface. Congeners of BPI are under biopharmaceutical development as novel anti-infective agents, highlighting the potential therapeutic relevance of this protein family.
Pubmed
Web of science
Création de la notice
24/10/2008 16:36
Dernière modification de la notice
20/08/2019 16:10
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