Significance of anticardiolipin antibodies on short and long term allograft survival and function following kidney transplantation

Détails

ID Serval
serval:BIB_A46F83AB26B7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Significance of anticardiolipin antibodies on short and long term allograft survival and function following kidney transplantation
Périodique
American Journal of Transplantation
Auteur(s)
Forman  J. P., Lin  J., Pascual  M., Denton  M. D., Tolkoff-Rubin  N.
ISSN
1600-6135
Statut éditorial
Publié
Date de publication
11/2004
Peer-reviewed
Oui
Volume
4
Numéro
11
Pages
1786-91
Notes
Journal Article --- Old month value: Nov
Résumé
The significance of anticardiolipin antibodies (ACAs) prior to renal transplantation is unclear. We studied a cohort of 337 patients who underwent renal transplantation from 1996 to 2001. Follow-up continued until allograft loss, patient death or 31 December 2002. The primary outcome was a composite endpoint of death-censored allograft loss or a 25% reduction in estimated glomerular filtration rate (GFR) from 1-month post-transplant. Secondary outcomes were allograft loss, a 25% reduction in GFR, acute rejection and creatinine at 1 year. IgG and IgM ACA titers were positive (> or =15) in 18.1% of recipients. There were no significant differences at baseline between recipients, except coumadin therapy in those with positive ACA titers (20% vs. 7.4%). Post-transplant, there was no increase in the primary outcome in ACA-positive patients, even after adjustment for anticoagulation with coumadin (HR = 1.42 [0.68, 2.96]). There was no difference in secondary outcomes between those with or without positive titers. Two of five patients with very high titers (>50) who were not anticoagulated had early graft loss. A positive ACA titer prior to kidney transplantation was not associated with inferior renal outcomes after transplantation, although more research is required to address the prognostic significance of very high ACA titers.
Mots-clé
Adult Antibodies, Anticardiolipin/*blood Antiphospholipid Syndrome/epidemiology Biological Markers/blood Cohort Studies Creatinine/blood Female Follow-Up Studies Glomerular Filtration Rate Glomerulonephritis/surgery Graft Rejection/epidemiology Graft Survival/*immunology Humans Kidney Failure, Chronic/etiology/surgery Kidney Transplantation/*immunology/mortality/pathology/physiology Male Middle Aged Retrospective Studies Survival Analysis Time Factors Tissue Donors/statistics & numerical data
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2008 13:53
Dernière modification de la notice
20/08/2019 15:09
Données d'usage