Surgery for primary cardiac tumors in children: early and late results in a multicenter European Congenital Heart Surgeons Association study.

Détails

ID Serval
serval:BIB_A440B38C25B4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Surgery for primary cardiac tumors in children: early and late results in a multicenter European Congenital Heart Surgeons Association study.
Périodique
Circulation
Auteur(s)
Padalino M.A., Vida V.L., Boccuzzo G., Tonello M., Sarris G.E., Berggren H., Comas J.V., Di Carlo D., Di Donato R.M., Ebels T., Hraska V., Jacobs J.P., Gaynor J.W., Metras D., Pretre R., Pozzi M., Rubay J., Sairanen H., Schreiber C., Maruszewski B., Basso C., Stellin G.
ISSN
1524-4539 (Electronic)
ISSN-L
0009-7322
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
126
Numéro
1
Pages
22-30
Langue
anglais
Résumé
BACKGROUND: To evaluate indications and results of surgery for primary cardiac tumors in children.
METHODS AND RESULTS: Eighty-nine patients aged ≤18 years undergoing surgery for cardiac tumor between 1990 and 2005 from 16 centers were included retrospectively (M/F=41/48; median age 4.3 months, range 1 day to 18 years). Sixty-three patients (68.5%) presented with symptoms. Surgery consisted of complete resection in 62 (69.7%) patients, partial resection in 21 (23.6%), and cardiac transplant in 4 (4.5%). Most frequent histotypes (93.2%) were benign (rhabdomyoma, myxoma, teratoma, fibroma, and hemangioma). Postoperative complications occurred in 29.9%. Early and late mortality were 4.5% each (mean follow-up, 6.3±4.4 years); major adverse events occurred in 28.2% of the patients; 90.7% of patients are in New York Heart Association class I. There were no statistically significant differences in survival, postoperative complications, or adverse events after complete and partial resection in benign tumors other than myxomas. Cardiac transplant was associated significantly with higher mortality rate (P=0.006). Overall mortality was associated to malignancy (P=0.0008), and adverse events during follow-up (P=0.005).
CONCLUSIONS: Surgery for primary cardiac tumors in children has good early and long-term outcomes, with low recurrence rate. Rhabdomyomas are the most frequent surgical histotypes. Malignant tumors negatively affect early and late survival. Heart transplant is indicated when conservative surgery is not feasible. Lack of recurrence after partial resection of benign cardiac tumors indicates that a less risky tumor debulking is effective for a subset of histotypes such as rhabdomyomas and fibromas.
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/12/2014 19:12
Dernière modification de la notice
20/08/2019 16:09
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