Poly(ADP-ribose) polymerase activation in the reperfused myocardium

Détails

ID Serval
serval:BIB_A433FEA4A776
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Poly(ADP-ribose) polymerase activation in the reperfused myocardium
Périodique
Cardiovascular Research
Auteur⸱e⸱s
Szabo  G., Liaudet  L., Hagl  S., Szabo  C.
ISSN
0008-6363 (Print)
Statut éditorial
Publié
Date de publication
02/2004
Volume
61
Numéro
3
Pages
471-80
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Feb 15
Résumé
The activation of poly(ADP-ribose) polymerase (PARP) is now considered a final common effector in various types of tissue injury including systemic inflammation, circulatory shock and ischemia/reperfusion. Free radical and oxidant production and related cytotoxicity during ischemia/reperfusion leads to DNA strand breakage which activates the nuclear enzyme PARP and initiates an energy-consuming, inefficient cellular metabolic cycle with transfer of the ADP-ribosyl moiety of NAD+ to protein acceptors. During the last 5 years, a growing number of experimental studies demonstrated the beneficial effects of PARP inhibition in cell cultures through rodent models and more recently in pre-clinical large animal models of regional and global ischemia/reperfusion injury. The objective of the current review is to provide an overview of the experimental evidence implicating PARP as a pathophysiological modulator of myocardial injury in vitro and in vivo.
Mots-clé
Animals Cells, Cultured Enzyme Activation Enzyme Inhibitors/therapeutic use Humans Models, Animal Myocardial Ischemia/enzymology Myocardial Reperfusion Injury/*enzymology Myocardium/*enzymology Niacinamide/therapeutic use Poly(ADP-ribose) Polymerases/antagonists & inhibitors/*metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 17:01
Dernière modification de la notice
20/08/2019 15:09
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