Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitor

Détails

ID Serval
serval:BIB_A40A712814FF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitor
Périodique
Gut
Auteur(s)
Borovicka J., Schwizer W., Guttmann G., Hartmann D., Kosinski M., Wastiel C., Bischof-Delaloye A., Fried M.
ISSN
0017-5749 (Print)
Statut éditorial
Publié
Date de publication
06/2000
Volume
46
Numéro
6
Pages
774-81
Notes
Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
BACKGROUND AND AIMS: To investigate the importance of lipase on gastric functions, we studied the effects of orlistat, a potent and specific inhibitor of lipase, on postprandial gastric acidity and gastric emptying of fat. METHODS: Fourteen healthy volunteers participated in a double blind, placebo controlled, randomised study. In a two way cross over study with two test periods of five days, separated by at least 14 days, orlistat 120 mg three times daily or placebo was given with standardised daily meals. In previous experiments we found that this dose almost completely inhibited postprandial duodenal lipase activity. Subjects underwent 28 hour intragastric pH-metry on day 4, and a gastric emptying study with a mixed meal (800 kcal) labelled with (999m)Tc sulphur colloid (solids) and (111In)thiocyanate (fat) on day 5. Gastric pH data were analysed for three postprandial hours and the interdigestive periods. RESULTS: Orlistat inhibited almost completely (by 75%) lipase activity and accelerated gastric emptying of both the solid (by 52%) and fat (by 44%) phases of the mixed meal (p<0.03). Orlistat increased postprandial gastric acidity (from a median pH of 3.3 to 2.7; p<0.01). Postprandial cholecystokinin release was lower with orlistat (p<0.03). CONCLUSION: Lipase has an important role in the regulation of postprandial gastric acid secretion and fat emptying in humans. These effects might be explained by lipolysis induced release of cholecystokinin.
Mots-clé
Adult Cholecystokinin/blood Dietary Fats/*pharmacokinetics Double-Blind Method Enzyme Inhibitors/pharmacology Female Gastric Acid/*secretion Gastric Emptying/physiology Gastrins/blood Humans Hydrogen-Ion Concentration Lactones/pharmacology Lipase/antagonists & inhibitors/*physiology Male Postprandial Period
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 12:21
Dernière modification de la notice
20/08/2019 16:09
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