Differential activation of the prefrontal cortex in successful and unsuccessful memory retrieval.
Détails
ID Serval
serval:BIB_A3C6FAFB31C1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Differential activation of the prefrontal cortex in successful and unsuccessful memory retrieval.
Périodique
Brain
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
1996
Volume
119 ( Pt 6)
Pages
2073-2083
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Six subjects underwent PET scans while they performed three versions of a recognition memory test for words and three versions of a control task. In each memory condition, the subjects discriminated between words presented in a prescan study list and words new to the experiment. During the 30 s scanning interval, the ratio of old and new words was 0:20, 4:16 or 16:4, depending on the experimental condition. Outside this interval, the ratio was 50:50 in all three conditions. The requirement in the control task was to discriminate between two character strings, the ratios of which were also manipulated during the 30 s scanning interval. Employing the control task as a covariate, analysis with statistical parametric mapping revealed that regional cerebral blood flow (rCBF) covaried with increasing density of old items in three regions of prefrontal cortex: right dorsolateral [Brodmann area (BA) 9/46], right medial (BA 32/8) and bilateral frontopolar cortex (BA 10). It is concluded that the prefrontal cortex, especially in the right hemisphere, is more active when a retrieval attempt succeeds than when it fails. This finding is consistent with the idea that the prefrontal cortex supports processes that operate selectively on the products of memory retrieval.
Mots-clé
Adult, Cerebrovascular Circulation, Humans, Male, Memory/physiology, Prefrontal Cortex/physiology, Prefrontal Cortex/radionuclide imaging
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/09/2011 17:04
Dernière modification de la notice
20/08/2019 15:09