Mutations of mitochondrial DNA as potential biomarkers in breast cancer.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_A3807E8F044E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mutations of mitochondrial DNA as potential biomarkers in breast cancer.
Périodique
Anticancer Research
Auteur(s)
Cai Feng Feng, Kohler Corina, Zhang Bei, Chen Wei Jie, Barekati Zeinab, Garritsen Henk S.P., Lenner Per, Toniolo Paolo, Zhang Jing Jie, Zhong Xiao Yan
ISSN
1791-7530 (Electronic)
ISSN-L
0250-7005
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
31
Numéro
12
Pages
4267-4271
Langue
anglais
Notes
http://ar.iiarjournals.org/content/31/12/4267.abstract
Résumé
BACKGROUND: Alterations of mitochondrial DNA (mtDNA) have been found in cancer patients, therefore informative mtDNA mutations could serve as biomarkers for the disease. MATERIALS AND METHODS: The two hypervariable regions HVR1 and HVR2 in the D-Loop region were sequenced in ten paired tissue and plasma samples from breast cancer patients. RESULTS: MtDNA mutations were found in all patients' samples, suggesting a 100% detection rate. Examining germline mtDNA mutations, a total of 85 mutations in the D-loop region were found; 31 of these mutations were detected in both tissues and matched plasma samples, the other 54 germline mtDNA mutations were found only in the plasma samples. Regarding somatic mtDNA mutations, a total of 42 mutations in the D-loop region were found in breast cancer tissues. CONCLUSION: Somatic mtDNA mutations in the D-loop region were detected in breast cancer tissues but not in the matched plasma samples, suggesting that more sensitive methods will be needed for such detection to be of clinical utility.
Pubmed
Web of science
Création de la notice
21/02/2012 17:27
Dernière modification de la notice
20/08/2019 15:09
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