The cerebellum is involved in multiple sclerosis (MS),
but its implication in early phases is still poorly
understood. We investigated structural and functional
cerebellar connectivity alterations in early and
minimally impaired MS patients, and their correlation to
patientsâeuro™ clinical status. We reconstructed the
connectomes of 28 MS patients and 16 healthy controls and
performed network statistical analysis. Structural
connectivity was found to be altered independently from
cerebellar lesion count, volume and disease duration; the
microstructural properties of altered connections
correlated with patientsâeuro™ motor and cognitive
performance. No topological reorganization or
compensatory mechanisms were observed at this stage.