Bone metabolism and risk of secondary hyperparathyroidism 12 months after gastric banding in obese pre-menopausal women.

Détails

ID Serval
serval:BIB_A2CF56FEEE7F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Bone metabolism and risk of secondary hyperparathyroidism 12 months after gastric banding in obese pre-menopausal women.
Périodique
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
Auteur⸱e⸱s
Pugnale N., Giusti V., Suter M., Zysset E., Héraïef E., Gaillard R.C., Burckhardt P.
ISSN
0307-0565
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
27
Numéro
1
Pages
110-6
Langue
anglais
Notes
Publication types: Evaluation Studies ; Journal Article - Publication Status: ppublish
Résumé
OBJECTIVE: To evaluate, during the first postoperative year in obese pre-menopausal women, the effects of laparoscopic gastric banding on calcium and vitamin D metabolism, the potential modifications of bone mineral content and bone mineral density, and the risk of development of secondary hyperparathyroidism. SUBJECTS: Thirty-one obese pre-menopausal women aged between 25 and 52 y with a mean body mass index (BMI) of 43.6 kg/m(2), scheduled for gastric banding were included. Patients with renal, hepatic, metabolic and bone disease were excluded. METHODS: Body composition and bone mineral density (BMD) were measured at baseline, 6 and 12 months after gastric banding using dual-energy X-ray absorptiometry. Serum calcium, phosphate, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, bilirubin, urea, creatinine, uric acid, proteins, parathormone, vitamin D(3), IGF-1, IGF-BP3 and telopeptide, as well as urinary telopeptide, were measured at baseline and 1, 3, 6, 9 and 12 months after surgery. RESULTS: After 1 y vitamin D3 remained stable and PTH decreased by 12%, but the difference was not significant. Serum telopeptide C increased significantly by 100% (P<0.001). There was an initial drop of the IGF-BP3 during the first 6 months (P<0.05), but the reduction was no longer significant after 1 y. The BMD of cortical bone (femoral neck) decreased significantly and showed a trend of a positive correlation with the increase of telopeptides (P<0.06). The BMD of trabecular bone, at the lumbar spine, increased proportionally to the reduction of hip circumference and of body fat. CONCLUSION: There is no evidence of secondary hyperparathyroidism 1 y after gastric banding. Nevertheless biochemical bone markers show a negative remodelling balance, characterized by an increase of bone resorption. The serum telopeptide seems to be a reliable parameter, not affected by weight loss, to follow up bone turnover after gastroplasty.
Mots-clé
Adult, Body Mass Index, Bone Density, Bone Remodeling, Calcium, Female, Follow-Up Studies, Gastric Bypass, Gastroscopy, Humans, Hyperparathyroidism, Secondary, Middle Aged, Obesity, Morbid, Premenopause, Risk Factors, Vitamin D
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/02/2008 16:57
Dernière modification de la notice
20/08/2019 15:08
Données d'usage