Single-shot, three-dimensional "non-echo" localization method for in vivo NMR spectroscopy.

Détails

ID Serval
serval:BIB_A2B3F1C921C2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Single-shot, three-dimensional "non-echo" localization method for in vivo NMR spectroscopy.
Périodique
Magnetic Resonance in Medicine
Auteur(s)
Choi I.Y., Tkác I., Gruetter R.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Statut éditorial
Publié
Date de publication
2000
Volume
44
Numéro
3
Pages
387-394
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
Metabolite signals with short T(1) or T(2) are difficult to localize with full sensitivity. This limitation was overcome with the development and implementation of a single-shot, complete three-dimensional "non-echo" localization method with reduced sensitivity to spatial B(1) variation, which is suitable for measuring signals with very short T(1) or T(2), e.g., the (13)C NMR signals of glycogen. The proposed method is based on a T(1)-optimized outer volume suppression scheme using pulses of the hyperbolic secant type applied at different power levels, which is robust over a fivefold range of T(1). Strong lipid, muscle glycogen, and glucose signals originating outside the rat brain were suppressed. Signals of glycogen, aspartate, glutathione, GABA C4, N-acetyl aspartate as well as the C3 and C4 signals of glutamate and glutamine with resolved homonuclear (13)C-(13)C coupling were fully resolved in vivo at 9.4 Tesla using higher-order shimming. The method can be extended to other nuclei and to localized MRS of humans.
Mots-clé
Acetates/analysis, Animals, Aspartic Acid/analogs & derivatives, Aspartic Acid/analysis, Brain Chemistry, Calibration, Carbon Isotopes/analysis, Evaluation Studies as Topic, Formates, Glucose/analysis, Glutamic Acid/analysis, Glutamine/analysis, Glycogen/analysis, Inositol/analysis, Lipids/analysis, Magnetic Resonance Spectroscopy/methods, Male, Muscle, Skeletal/chemistry, Ostreidae, Phantoms, Imaging, Protons, Radio Waves, Rats, Sensitivity and Specificity, gamma-Aminobutyric Acid/analysis
Pubmed
Web of science
Création de la notice
04/08/2010 15:28
Dernière modification de la notice
20/08/2019 15:08
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