Natural antibody response to Plasmodium falciparum Exp-1, MSP-3 and GLURP long synthetic peptides and association with protection

Détails

ID Serval
serval:BIB_A2A4A99A281C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Natural antibody response to Plasmodium falciparum Exp-1, MSP-3 and GLURP long synthetic peptides and association with protection
Périodique
Parasite Immunology
Auteur(s)
Meraldi  V., Nebie  I., Tiono  A. B., Diallo  D., Sanogo  E., Theisen  M., Druilhe  P., Corradin  G., Moret  R., Sirima  B. S.
ISSN
0141-9838 (Print)
Statut éditorial
Publié
Date de publication
07/2004
Volume
26
Numéro
6-7
Pages
265-72
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun-Jul
Résumé
A longitudinal study was undertaken in Burkina Faso among 293 children aged 6 months to 9 years in order to determine the correlation between an antibody response to several individual malarial antigens and malarial infection. It was found that the presence of a positive antibody response at the beginning of the rainy season to three long synthetic peptides corresponding to Plasmodium falciparum Exp-1 101-162, MSP-3 154-249 and GLURP 801-920 but not to CSP 274-375 correlated with a statistically significant decrease in malarial infection during the ongoing transmission season. The simultaneous presence of an antibody response to more than one antigen is indicative of a lower frequency of malarial infection. This gives scientific credibility to the notion that a successful malaria vaccine should contain multiple antigens.
Mots-clé
Animals Antibodies, Protozoan/*blood Antigens, Protozoan/*immunology Burkina Faso Child Child, Preschool Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Female Humans Immunoglobulin G/blood Infant Longitudinal Studies Malaria, Falciparum/*immunology/prevention & control Male Oligopeptides/*immunology Plasmodium falciparum/*immunology Protozoan Proteins/*immunology
Pubmed
Web of science
Création de la notice
24/01/2008 15:55
Dernière modification de la notice
20/08/2019 16:08
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