Natural antibody response to Plasmodium falciparum Exp-1, MSP-3 and GLURP long synthetic peptides and association with protection
Détails
ID Serval
serval:BIB_A2A4A99A281C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Natural antibody response to Plasmodium falciparum Exp-1, MSP-3 and GLURP long synthetic peptides and association with protection
Périodique
Parasite Immunology
ISSN
0141-9838 (Print)
Statut éditorial
Publié
Date de publication
07/2004
Volume
26
Numéro
6-7
Pages
265-72
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun-Jul
Research Support, Non-U.S. Gov't --- Old month value: Jun-Jul
Résumé
A longitudinal study was undertaken in Burkina Faso among 293 children aged 6 months to 9 years in order to determine the correlation between an antibody response to several individual malarial antigens and malarial infection. It was found that the presence of a positive antibody response at the beginning of the rainy season to three long synthetic peptides corresponding to Plasmodium falciparum Exp-1 101-162, MSP-3 154-249 and GLURP 801-920 but not to CSP 274-375 correlated with a statistically significant decrease in malarial infection during the ongoing transmission season. The simultaneous presence of an antibody response to more than one antigen is indicative of a lower frequency of malarial infection. This gives scientific credibility to the notion that a successful malaria vaccine should contain multiple antigens.
Mots-clé
Animals
Antibodies, Protozoan/*blood
Antigens, Protozoan/*immunology
Burkina Faso
Child
Child, Preschool
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G/blood
Infant
Longitudinal Studies
Malaria, Falciparum/*immunology/prevention & control
Male
Oligopeptides/*immunology
Plasmodium falciparum/*immunology
Protozoan Proteins/*immunology
Pubmed
Web of science
Création de la notice
24/01/2008 14:55
Dernière modification de la notice
20/08/2019 15:08