Targeting the TGFβ pathway for cancer therapy.

Détails

ID Serval
serval:BIB_A25EA6ACF6B9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Targeting the TGFβ pathway for cancer therapy.
Périodique
Pharmacology and Therapeutics
Auteur⸱e⸱s
Neuzillet C., Tijeras-Raballand A., Cohen R., Cros J., Faivre S., Raymond E., de Gramont A.
ISSN
1879-016X (Electronic)
ISSN-L
0163-7258
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
147C
Pages
22-31
Langue
anglais
Notes
Publication types: <Publication Status: ppublish
Résumé
The TGFβ signaling pathway has pleiotropic functions regulating cell growth, differentiation, apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune response. TGFβ signaling deregulation is frequent in tumors and has crucial roles in tumor initiation, development and metastasis. TGFβ signaling inhibition is an emerging strategy for cancer therapy. The role of the TGFβ pathway as a tumor-promoter or suppressor at the cancer cell level is still a matter of debate, due to its differential effects at the early and late stages of carcinogenesis. In contrast, at the microenvironment level, the TGFβ pathway contributes to generate a favorable microenvironment for tumor growth and metastasis throughout all the steps of carcinogenesis. Then, targeting the TGFβ pathway in cancer may be considered primarily as a microenvironment-targeted strategy. In this review, we focus on the TGFβ pathway as a target for cancer therapy. In the first part, we provide a comprehensive overview of the roles played by this pathway and its deregulation in cancer, at the cancer cell and microenvironment levels. We go on to describe the preclinical and clinical results of pharmacological strategies to target the TGFβ pathway, with a highlight on the effects on tumor microenvironment. We then explore the perspectives to optimize TGFβ inhibition therapy in different tumor settings.
Pubmed
Open Access
Oui
Création de la notice
11/02/2015 12:04
Dernière modification de la notice
20/08/2019 15:08
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