Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_A24A5D715550
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation.
Périodique
Mucosal immunology
Auteur⸱e⸱s
Trompette A., Pernot J., Perdijk O., Alqahtani RAA, Domingo J.S., Camacho-Muñoz D., Wong N.C., Kendall A.C., Wiederkehr A., Nicod L.P., Nicolaou A., von Garnier C., Ubags NDJ, Marsland B.J.
ISSN
1935-3456 (Electronic)
ISSN-L
1933-0219
Statut éditorial
Publié
Date de publication
05/2022
Peer-reviewed
Oui
Volume
15
Numéro
5
Pages
908-926
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function is linked with enhanced allergen sensitization and the development of diseases such as atopic dermatitis (AD), which can precede the development of other allergic disorders, for example, food allergies and asthma. Epidemiological evidence indicates that children suffering from allergies have lower levels of dietary fibre-derived short-chain fatty acids (SCFA). Using an experimental model of AD-like skin inflammation, we report that a fermentable fibre-rich diet alleviates systemic allergen sensitization and disease severity. The gut-skin axis underpins this phenomenon through SCFA production, particularly butyrate, which strengthens skin barrier function by altering mitochondrial metabolism of epidermal keratinocytes and the production of key structural components. Our results demonstrate that dietary fibre and SCFA improve epidermal barrier integrity, ultimately limiting early allergen sensitization and disease development.The Graphical Abstract was designed using Servier Medical Art images ( https://smart.servier.com ).
Mots-clé
Allergens, Child, Dermatitis, Atopic, Dietary Fiber, Fatty Acids, Volatile, Food Hypersensitivity, Humans, Keratinocytes
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/06/2022 16:34
Dernière modification de la notice
23/11/2022 7:13
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