Serial observations on the pathophysiology of acute stroke. The transition from ischaemia to infarction as reflected in regional oxygen extraction.

Détails

ID Serval
serval:BIB_A249F1E3EC32
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Serial observations on the pathophysiology of acute stroke. The transition from ischaemia to infarction as reflected in regional oxygen extraction.
Périodique
Brain
Auteur⸱e⸱s
Wise R.J., Bernardi S., Frackowiak R.S., Legg N.J., Jones T.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
1983
Volume
106 (Pt 1)
Pages
197-222
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Regional cerebral blood flow, fractional oxygen extraction and oxygen metabolism have been measured in 34 patients after acute nonhaemorrhagic cerebral hemispheric infarction. Nine cases showed elevated oxygen extraction in the region of the early infarct, and these were the patients studied earliest after the onset of stroke. The results of serial studies to follow the evolution of the pathophysiology of acute stroke in these 9 patients are presented. The elevated oxygen extraction within the early infarct showed a significant reduction over the week following the onset of stroke. The reason for this fall in the fractional use of available oxygen varied in individual cases, and at the extremes was associated with a marked reduction in oxygen metabolism with a further small fall in residual blood flow, or a return of flow without recovery of oxygen metabolism. The significance of oxygen extraction in terms of potential viability of the tissue is discussed. The finding of a lower oxygen extraction in subcortical grey and white matter compared to cortex within the first hours or days of a major stroke is considered indicative of an earlier change from ischaemia to infarction in the deep tissues, probably related to the anatomy of the microvasculature. The interpretation of the results in the light of knowledge accumulated from studies of ischaemia in animals is presented, and problems imposed on data analysis by current limitations in positron emission tomography are discussed.
Mots-clé
Adult, Aged, Blood Pressure, Brain Ischemia/complications, Brain Ischemia/physiopathology, Cerebral Infarction/etiology, Cerebral Infarction/metabolism, Cerebrovascular Circulation, Cerebrovascular Disorders/physiopathology, Female, Humans, Ischemic Attack, Transient/radionuclide imaging, Male, Oxygen Consumption, Thalamus/physiopathology, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
09/10/2011 17:48
Dernière modification de la notice
20/08/2019 15:08
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