A gene expression signature that distinguishes desmoid tumours from nodular fasciitis.

Détails

ID Serval
serval:BIB_A1FADE5BA67C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A gene expression signature that distinguishes desmoid tumours from nodular fasciitis.
Périodique
Journal of Pathology
Auteur(s)
Bacac M., Migliavacca E., Stehle J.C., McKee T., Delorenzi M., Coindre J.M., Guillou L., Stamenkovic I.
ISSN
0022-3417 (Print)
ISSN-L
0022-3417
Statut éditorial
Publié
Date de publication
2006
Volume
208
Numéro
4
Pages
543-553
Langue
anglais
Résumé
Nodular fasciitis (NF) is a rapidly growing cellular mass composed of fibroblasts/myofibroblasts, usually localized in subcutaneous tissues, that typically undergoes fibrosis and almost never recurs. Desmoid tumours (DTs) are rare forms of fibroblastic/myofibroblastic growth that arise in deep soft tissues, display a propensity for local infiltration and recurrence, but fail to metastasize. Given that both entities are primarily fibroblastic/myofibroblastic lesions with overlapping histological features, their gene expression profiles were compared to identify differentially expressed genes that may provide not only potential diagnostic markers, but also clues as to the pathogenesis of each disorder. Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). Remarkably, almost one-quarter of the differentially expressed genes encode proteins associated with inflammation and tissue remodelling, including members of the interferon (IFN), tumour necrosis factor (TNF), and transforming growth factor beta (TGF-beta) signalling pathways as well as metalloproteinases (MMP1, 9, 13, 23), urokinase plasminogen activator (PLAU), and cathepsins. The observations provide the first comparative molecular characterization of desmoid tumours and nodular fasciitis and suggest that selected tyrosine kinases, transcription factors, and members of the Wnt, TGF-beta, IFN, and TNF signalling pathways may be implicated in influencing and distinguishing their fate.
Mots-clé
Adolescent, Adult, Cell Differentiation/genetics, Child, Preschool, Diagnosis, Differential, Fasciitis/diagnosis, Fasciitis/genetics, Female, Fibromatosis, Aggressive/diagnosis, Fibromatosis, Aggressive/genetics, Gene Expression Profiling, Genes, Tumor Suppressor, Humans, Immunohistochemistry/methods, Inflammation, Male, Middle Aged, Neurons/cytology, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction/genetics, Tumor Markers, Biological, Tumor Necrosis Factor-alpha/genetics, Wnt Proteins/genetics, beta Catenin/genetics
Pubmed
Web of science
Création de la notice
29/01/2008 19:33
Dernière modification de la notice
20/08/2019 16:08
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