Changes in protein turnover and resting energy expenditure after treatment of malaria in Gambian children.
Détails
ID Serval
serval:BIB_A1E684670A70
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Changes in protein turnover and resting energy expenditure after treatment of malaria in Gambian children.
Périodique
Pediatric Research
ISSN
0031-3998 (Print)
ISSN-L
0031-3998
Statut éditorial
Publié
Date de publication
03/1996
Volume
39
Numéro
3
Pages
401-409
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
To explore the changes in resting energy expenditure (REE) and whole body protein turnover induced by malaria, 23 children aged 6 to 14 y (23.9 +/- 1.0 kg, 1.3 +/- 0.02 m) were studied on three separate days after treatment (d 1, d 2, and 15 d later). REE was assessed by indirect calorimetry (hood), whereas whole body protein turnover was estimated using a single dose of [15N]glycine administered p.o. by measuring the isotopic enrichment of [15N]ammonia in urine over 12 h. Within the first 3.5 h after treatment, the body temperature dropped from 39.8 +/- 0.1 to 37.8 +/- 0.1 degrees C (p < 0.0001), and REE followed the same pattern, decreasing rapidly from 223 +/- 6 to 187 +/- 4 kJ/kg/d (p < 0.0001). Whole body protein synthesis and breakdown were significantly higher during the 1st day (5.65 +/- 0.38 and 6.21 +/- 0.43 g/kg/d, respectively) than at d 15 (2.95 +/- 0.17 and 2.77 +/- 0.2 g/kg/d). It is concluded that Gambian children suffering from an acute episode of malaria have an increased REE averaging 37% of the control value (d 15) and that this was associated with a substantial increase (by a factor of 2) in whole body protein turnover. A rapid normalization of the hypermetabolism and protein hypercatabolism states after treatment was observed.
Mots-clé
Acetaminophen/pharmacology, Adolescent, Body Mass Index, Body Temperature, Body Weight, Child, Chloroquine/analogs & derivatives, Chloroquine/pharmacology, Energy Metabolism, Gambia, Heart Rate, Humans, Malaria, Falciparum/drug therapy, Malaria, Falciparum/metabolism, Proteins/metabolism, Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2008 14:08
Dernière modification de la notice
20/08/2019 16:07