Prognostic Impact of Time to Surgery in Patients With Resectable Pancreatic Ductal Adenocarcinoma.

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Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_A15C9BC44187
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prognostic Impact of Time to Surgery in Patients With Resectable Pancreatic Ductal Adenocarcinoma.
Périodique
Pancreas
Auteur⸱e⸱s
Joliat G.R., Labgaa I., Gilgien J., Demartines N.
ISSN
1536-4828 (Electronic)
ISSN-L
0885-3177
Statut éditorial
Publié
Date de publication
01/01/2021
Peer-reviewed
Oui
Volume
50
Numéro
1
Pages
104-110
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Some studies suggested the importance of performing pancreatoduodenectomy expeditiously in resectable pancreatic ductal adenocarcinoma (PDAC). This study aimed to assess the prognostic value of time to surgery in patients undergoing pancreatoduodenectomy for PDAC.
All PDAC patients who underwent upfront pancreatoduodenectomy were collected (2000-2015). Diagnosis date was the computed tomography scan date where a suspicious pancreatic head lesion was observed. Survival analyses were performed using Kaplan-Meier method. Cox model was used to find predictive factors of survival.
A total of 192 patients underwent pancreatoduodenectomy. The median time to surgery was 27 days (interquartile range, 17-40 days). The best dichotomous threshold for 24-month overall survival (OS) was 30 days. The median OS was similar between groups with time to surgery of fewer than 30 days and time to surgery of 30 days or more (25 vs 21 months, P = 0.609). Similar results were found for median recurrence-free survivals (19 vs 15 months, P = 0.561). On Cox regressions, time to surgery was not associated with shorter OS. Only lymph node invasion and adjuvant chemotherapy were independent OS predictors (hazard ratio, 2.610, P = 0.006, and hazard ratio, 2.042, P = 0.001).
Delaying surgery 30 days or more after diagnostic computed tomography scan was not associated with poorer OS and recurrence-free survival. Moreover, time to surgery was not prognostic of OS.
Pubmed
Web of science
Création de la notice
11/01/2021 10:31
Dernière modification de la notice
26/07/2022 6:37
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