Effets extra-rénaux du facteur natriurétique auriculaire [Extrarenal effects of the atrial natriuretic factor]

Détails

ID Serval
serval:BIB_A140A15BE9B4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effets extra-rénaux du facteur natriurétique auriculaire [Extrarenal effects of the atrial natriuretic factor]
Périodique
Néphrologie
Auteur⸱e⸱s
Biollaz J., Goy J.J., Nussberger J., Waeber B., Brunner H.R.
ISSN
0250-4960
Statut éditorial
Publié
Date de publication
1987
Peer-reviewed
Oui
Volume
8
Numéro
1
Pages
13-7
Langue
français
Notes
Publication types: English Abstract ; Journal Article - Publication Status: ppublish
Résumé
The synthesis of peptides which have the natriuretic and vasodilator properties of the atrial natriuretic factor has made it possible to study the physiological role of this recently discovered hormonal system. In addition to renal effects, atrial natriuretic peptides exert vascular, hemodynamic and endocrine actions which may participate in the regulation of plasma and interstitial volume as well as arterial blood pressure. Its acute hypotensive effect, which was observed in normal volunteers and in patients with cardiac failure or hypertension, is not entirely explained by its direct vasodilator effect. The complexity of its role is demonstrated by its inhibiting action on the synthesis and/or the activity of other vasoactive hormones. The observed increase in hematocrit suggests that vascular permeability may be enhanced; the resulting consequences, e.g. on blood viscosity, still need to be elucidated. When infusing atrial natriuretic peptides, there exists a clear delay between the moment steady-state plasma levels are achieved and peak effect occurs. This renders the interpretation of the results very difficult. At this moment, the physiological role of atrial natriuretic peptides as well as their potential future use as therapeutic agents cannot yet be fully appreciated.
Mots-clé
Atrial Natriuretic Factor, Blood Pressure, Hematocrit, Hemodynamics, Humans, Liver Circulation, Regional Blood Flow, Renal Circulation, Renin-Angiotensin System, Skin, Vasodilation
Pubmed
Web of science
Création de la notice
05/03/2008 17:39
Dernière modification de la notice
20/08/2019 16:07
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