Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?

Détails

ID Serval
serval:BIB_A0CF6D943568
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?
Périodique
Journal of Clinical Investigation
Auteur(s)
Saas  P., Walker  P. R., Hahne  M., Quiquerez  A. L., Schnuriger  V., Perrin  G., French  L., Van Meir  E. G., de Tribolet  N., Tschopp  J., Dietrich  P. Y.
ISSN
0021-9738 (Print)
Statut éditorial
Publié
Date de publication
03/1997
Volume
99
Numéro
6
Pages
1173-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 15
Résumé
Astrocytomas are among the most common brain tumors that are usually fatal in their malignant form. They appear to progress without significant impedance from the immune system, despite the presence of intratumoral T cell infiltration. To date, this has been thought to be the result of T cell immunosuppression induced by astrocytoma-derived cytokines. Here, we propose that cell contact-mediated events also play a role, since we demonstrate the in vivo expression of Fas ligand (FasL/CD95L) by human astrocytoma and the efficient killing of Fas-bearing cells by astrocytoma lines in vitro and by tumor cells ex vivo. Functional FasL is expressed by human, mouse, and rat astrocytoma and hence may be a general feature of this nonlymphoid tumor. In the brain, astrocytoma cells can potentially deliver a death signal to Fas+ cells which include infiltrating leukocytes and, paradoxically, astrocytoma cells themselves. The expression of FasL by astrocytoma cells may extend the processes that are postulated to occur in normal brain to maintain immune privilege, since we also show FasL expression by neurons. Overall, our findings suggest that FasL-induced apoptosis by astrocytoma cells may play a significant role in both immunosuppression and the regulation of tumor growth within the central nervous system.
Mots-clé
Animals Antigens, CD95/*metabolism Astrocytoma/*immunology/metabolism/pathology Brain/*immunology/metabolism/pathology Brain Neoplasms/*immunology/metabolism/pathology Cytotoxicity Tests, Immunologic Fas Ligand Protein Humans Ligands Membrane Glycoproteins/*biosynthesis/physiology Mice Rats Tumor Cells, Cultured
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:19
Dernière modification de la notice
20/08/2019 15:06
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