Reduction in T gamma delta cell numbers and alteration in subset distribution in systemic lupus erythematosus
Détails
ID Serval
serval:BIB_A092E039C813
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Reduction in T gamma delta cell numbers and alteration in subset distribution in systemic lupus erythematosus
Périodique
Clinical and Experimental Immunology
ISSN
0009-9104 (Print)
Statut éditorial
Publié
Date de publication
11/1991
Volume
86
Numéro
2
Pages
203-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
We have studied the distribution of T gamma delta cells in the peripheral blood of 35 patients with systemic lupus erythematosus (SLE) and 36 age-matched controls. The monoclonal antibodies A13, BB3 and Ti gamma A, which are specific for the V delta 1, V delta 2 and V delta 9 gene products respectively, were used to define T gamma delta cell subsets. A significantly lower frequency of T gamma delta cells was found in peripheral blood lymphocytes of SLE patients compared with normal subjects (3.2% versus 5.9%). There was a marked reduction in the V delta 2+ subset of T gamma delta cells, which resulted in a reversal of the ratio of V delta 2+/V delta 1+ cells from 4.34 to 0.56. No correlation was found with either clinical or laboratory measures of disease activity. These results suggest that the observed changed in T gamma delta subset distribution are related to the SLE itself, and not secondary to changes in disease activity.
Mots-clé
Antigens, CD3
Antigens, Differentiation, T-Lymphocyte/analysis
Humans
Lupus Erythematosus, Systemic/*immunology/physiopathology
Receptors, Antigen, T-Cell/analysis
Receptors, Antigen, T-Cell, gamma-delta/analysis
T-Lymphocyte Subsets/*immunology
Pubmed
Web of science
Création de la notice
25/01/2008 9:38
Dernière modification de la notice
20/08/2019 16:06