CD4 T cells in the rheumatoid joint are oligoclonally activated and change during the course of disease

Détails

ID Serval
serval:BIB_A07529CD2FC8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
CD4 T cells in the rheumatoid joint are oligoclonally activated and change during the course of disease
Périodique
Annals of the Rheumatic Diseases
Auteur⸱e⸱s
Khazaei  H. A., Lunardi  C., So  A. K.
ISSN
0003-4967 (Print)
Statut éditorial
Publié
Date de publication
04/1995
Volume
54
Numéro
4
Pages
314-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
OBJECTIVE--To assess the nature of T cell receptor (TCR) utilisation by CD4 T cells in the rheumatoid joint. METHODS--Sequencing of the joining (NDJ) region of TCR beta chain mRNA isolated from synovial fluid CD4 T cells was performed in three patients in order to determine if oligoclonal expansion of particular sequences was present. Two patients were studied longitudinally to determine if these sequences changed over time. RESULTS--A number of dominant clonotypes were found within the TCR transcripts sequenced in each patient. In the two patients who were studied longitudinally, different dominant clonotypes were detected over time. No single clonotype was persistently dominant during the period of study. CONCLUSIONS--The pattern of TCR usage showed multiple oligoclonally expanded CD4 T cells within the rheumatoid joint. The change in clonotypes within the joint over time suggests that different antigens may be able to elicit synovial inflammation during the course of rheumatoid disease.
Mots-clé
Arthritis, Rheumatoid/*immunology Base Sequence CD4-Positive T-Lymphocytes/*immunology Clone Cells/immunology Female Humans Longitudinal Studies Lymphocyte Activation/*immunology Male Molecular Sequence Data RNA, Messenger/genetics Receptors, Antigen, T-Cell, alpha-beta/genetics/metabolism Synovial Fluid/*immunology T-Lymphocyte Subsets/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 8:39
Dernière modification de la notice
20/08/2019 15:06
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