Radiation-induced modifications of the tumor microenvironment promote metastasis.

Détails

ID Serval
serval:BIB_A068EFD16369
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Radiation-induced modifications of the tumor microenvironment promote metastasis.
Périodique
Bulletin du Cancer
Auteur(s)
Rüegg C., Monnier Y., Kuonen F., Imaizumi N.
ISSN
1769-6917 (Electronic)
ISSN-L
0007-4551
Statut éditorial
Publié
Date de publication
2011
Volume
98
Numéro
6
Pages
47-57
Langue
anglais
Résumé
Radiotherapy is successfully used to treat cancer. Emerging evidence, however, indicates that recurrences after radiotherapy are associated with increased local invasion, metastatic spreading and poor prognosis. Radiation-induced modifications of the tumor microenvironment have been proposed to contribute to increased aggressive tumor behavior, an effect also referred to as tumor bed effect, but the putative mechanisms involved have remained largely elusive. We have recently demonstrated that irradiation of the prospective tumor stroma impairs de novo angiogenesis through sustained inhibition of proliferation, migration and sprouting of endothelial cells. Experimental tumors growing within a pre-irradiated field have reduced tumor angiogenesis and tumor growth, increased hypoxia, necrosis, local invasion and distant metastasis. Mechanisms of progression involve adaptation of tumor cells to local hypoxic conditions as well as selection of cells with invasive and metastatic capacities. The matricellular protein CYR61 and integrin αVβ5 emerged as molecules that cooperate to mediate lung metastasis. Cilengitide, a small molecular inhibitor of αV integrins prevented lung metastasis formation. These results represent a conceptual advance to the understanding of the tumor bed effect and indicate that αV integrin inhibition might be a potential therapeutic approach for preventing metastasis in patients at risk for post-radiation recurrences.
Pubmed
Web of science
Création de la notice
04/07/2011 12:58
Dernière modification de la notice
20/08/2019 15:06
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