Effects of fructose on hepatic glucose metabolism in humans.

Détails

ID Serval
serval:BIB_A004561C4673
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of fructose on hepatic glucose metabolism in humans.
Périodique
American Journal of Physiology. Endocrinology and Metabolism
Auteur⸱e⸱s
Dirlewanger M., Schneiter P., Jéquier E., Tappy L.
ISSN
0193-1849 (Print)
ISSN-L
0193-1849
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
279
Numéro
4
Pages
E907-E911
Langue
anglais
Résumé
Hepatic and extrahepatic insulin sensitivity was assessed in six healthy humans from the insulin infusion required to maintain an 8 mmol/l glucose concentration during hyperglycemic pancreatic clamp with or without infusion of 16.7 micromol. kg(-1). min(-1) fructose. Glucose rate of disappearance (GR(d)), net endogenous glucose production (NEGP), total glucose output (TGO), and glucose cycling (GC) were measured with [6,6-(2)H(2)]- and [2-(2)H(1)]glucose. Hepatic glycogen synthesis was estimated from uridine diphosphoglucose (UDPG) kinetics as assessed with [1-(13)C]galactose and acetaminophen. Fructose infusion increased insulin requirements 2.3-fold to maintain blood glucose. Fructose infusion doubled UDPG turnover, but there was no effect on TGO, GC, NEGP, or GR(d) under hyperglycemic pancreatic clamp protocol conditions. When insulin concentrations were matched during a second hyperglycemic pancreatic clamp protocol, fructose administration was associated with an 11.1 micromol. kg(-1). min(-1) increase in TGO, a 7.8 micromol. kg(-1). min(-1) increase in NEGP, a 2.2 micromol. kg(-1). min(-1) increase in GC, and a 7.2 micromol. kg(-1). min(-1) decrease in GR(d) (P < 0. 05). These results indicate that fructose infusion induces hepatic and extrahepatic insulin resistance in humans.
Mots-clé
Adult, Blood Glucose, Carbon Isotopes, Deuterium, Female, Fructose/administration & dosage, Fructose/metabolism, Glucagon/administration & dosage, Glucose/metabolism, Glucose Clamp Technique, Glucose-6-Phosphate/metabolism, Humans, Hyperglycemia/chemically induced, Hyperglycemia/metabolism, Infusions, Intravenous, Insulin/administration & dosage, Insulin/blood, Liver/drug effects, Liver/metabolism, Male, Somatostatin/administration & dosage, Uridine Diphosphate Glucose/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
20/08/2019 16:06
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