Role of the GNOM gene in Arabidopsis apical-basal patterning--From mutant phenotype to cellular mechanism of protein action.

Détails

ID Serval
serval:BIB_9FB7C53F4EA7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Role of the GNOM gene in Arabidopsis apical-basal patterning--From mutant phenotype to cellular mechanism of protein action.
Périodique
European Journal of Cell Biology
Auteur⸱e⸱s
Richter S., Anders N., Wolters H., Beckmann H., Thomann A., Heinrich R., Schrader J., Singh M.K., Geldner N., Mayer U., Jürgens G.
ISSN
1618-1298[electronic], 0171-9335[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
89
Numéro
2-3
Pages
138-144
Langue
anglais
Résumé
How the apical-basal axis of polarity is established in embryogenesis is still a mystery in plant development. This axis appeared specifically compromised by mutations in the Arabidopsis GNOM gene. Surprisingly, GNOM encodes an ARF guanine-nucleotide exchange factor (ARF-GEF) that regulates the formation of vesicles in membrane trafficking. In-depth functional analysis of GNOM and its closest relative, GNOM-LIKE 1 (GNL1), has provided a mechanistic explanation for the development-specific role of a seemingly mundane trafficking regulator. The current model proposes that GNOM is specifically involved in the endosomal recycling of the auxin-efflux carrier PIN1 to the basal plasma membrane in provascular cells, which in turn is required for the accumulation of the plant hormone auxin at the future root pole through polar auxin transport. Thus, the analysis of GNOM highlights the importance of cell-biological processes for a mechanistic understanding of development.
Mots-clé
Animals, Arabidopsis/embryology, Arabidopsis/genetics, Arabidopsis Proteins/classification, Arabidopsis Proteins/genetics, Cell Membrane/metabolism, Cloning, Molecular, Guanine Nucleotide Exchange Factors/classification, Guanine Nucleotide Exchange Factors/genetics, Morphogenesis/physiology, Mutation, Phenotype, Phylogeny
Pubmed
Web of science
Création de la notice
13/01/2010 13:21
Dernière modification de la notice
20/08/2019 16:05
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