Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model.

Détails

ID Serval
serval:BIB_9FA94B594594
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model.
Périodique
Nature communications
Auteur⸱e⸱s
Brown E.M., Wlodarska M., Willing B.P., Vonaesch P., Han J., Reynolds L.A., Arrieta M.C., Uhrig M., Scholz R., Partida O., Borchers C.H., Sansonetti P.J., Finlay B.B.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
04/08/2015
Peer-reviewed
Oui
Volume
6
Pages
7806
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Environmental enteropathy (EE) is a subclinical chronic inflammatory disease of the small intestine and has a profound impact on the persistence of childhood malnutrition worldwide. However, the aetiology of the disease remains unknown and no animal model exists to date, the creation of which would aid in understanding this complex disease. Here we demonstrate that early-life consumption of a moderately malnourished diet, in combination with iterative oral exposure to commensal Bacteroidales species and Escherichia coli, remodels the murine small intestine to resemble features of EE observed in humans. We further report the profound changes that malnutrition imparts on the small intestinal microbiota, metabolite and intraepithelial lymphocyte composition, along with the susceptibility to enteric infection. Our findings provide evidence indicating that both diet and microbes combine to contribute to the aetiology of EE, and describe a novel murine model that can be used to elucidate the mechanisms behind this understudied disease.
Mots-clé
Animals, Bacteroides, Diet/adverse effects, Disease Models, Animal, Escherichia coli, Female, Growth, Intestinal Diseases/metabolism, Intestinal Diseases/microbiology, Intestine, Small/metabolism, Intestine, Small/microbiology, Intestine, Small/physiopathology, Lymphocytes/physiology, Malnutrition/metabolism, Malnutrition/microbiology, Malnutrition/physiopathology, Metabolome, Mice, Inbred C57BL, Microbiota, Random Allocation
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/08/2022 15:26
Dernière modification de la notice
03/01/2025 16:38
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