Quantitative Susceptibility Mapping of Amyloid-β Aggregates in Alzheimer's Disease with 7T MR.

Détails

ID Serval
serval:BIB_9F8047D7EE78
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Quantitative Susceptibility Mapping of Amyloid-β Aggregates in Alzheimer's Disease with 7T MR.
Périodique
Journal of Alzheimer's disease
Auteur⸱e⸱s
Tiepolt S., Schäfer A., Rullmann M., Roggenhofer E., Gertz H.J., Schroeter M.L., Patt M., Bazin P.L., Jochimsen T.H., Turner R., Sabri O., Barthel H.
Collaborateur⸱rice⸱s
Netherlands Brain Bank
ISSN
1875-8908 (Electronic)
ISSN-L
1387-2877
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
64
Numéro
2
Pages
393-404
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
PET imaging is an established technique to detect cerebral amyloid-β (Aβ) plaques in vivo. Some preclinical and postmortem data report an accumulation of redox-active iron near Aβ plaques. Quantitative susceptibility mapping (QSM) at high-field MRI enables iron deposits to be depicted with high spatial resolution.
Aim of this study was to examine whether iron and Aβ plaque accumulation is related and thus, whether 7T MRI might be an additive diagnostic tool to Aβ PET imaging.
Postmortem human Alzheimer's disease (AD) and healthy control (HC) frontal gray matter (GM) was imaged with 7T MRI which resulted in T1 maps and QSM. Aβ plaque load was determined by histopathology. In vivo, 10 Aβ PET-positive AD patients (74.1±6.0a) and 10 Aβ PET-negative HCs (67.1±4.4a) underwent 7T MR examination and QSM maps were analyzed. Severity of cognitive deficits was determined by MMSE.
Postmortem, the susceptibility of Aβ plaque-containing GM were higher than those of Aβ plaque-free GM (0.011±0.002 versus - 0.008±0.003 ppm, p < 0.001). In vivo, only the bilateral globus pallidus showed significantly higher susceptibility in AD patients compared to HCs (right: 0.277±0.018 versus - 0.009±0.009 ppm; left: 0.293±0.014 versus - 0.007±0.012 ppm, p < 0.0001). The pallidal QSM values were negatively correlated with those of the MMSE (r = - 0.69, p = 0.001).
The postmortem study revealed significant susceptibility differences between the Aβ plaque-containing and Aβ plaque-free GM, whereas in vivo only the QSM values of the globus pallidus differed significantly between AD and HC group. The pallidal QSM values correlated with the severity of cognitive deficits. These findings encourage efforts to optimize the 7T-QSM methodology.
Mots-clé
Aged, Aged, 80 and over, Alzheimer Disease/diagnostic imaging, Alzheimer Disease/metabolism, Amyloid beta-Peptides, Analysis of Variance, Brain Mapping, Diagnosis, Female, Frontal Lobe/diagnostic imaging, Frontal Lobe/metabolism, Functional Laterality, Gray Matter/diagnostic imaging, Gray Matter/metabolism, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Plaque, Amyloid/pathology, Positron-Emission Tomography, 7T MRI, Alzheimer’s disease, amyloid, iron accumulation, quantitative susceptibility mapping
Pubmed
Web of science
Création de la notice
15/06/2018 16:48
Dernière modification de la notice
20/08/2019 15:05
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