Synthesis of new pyrrolidine derivatives as inhibitors of alpha-mannosidase and of the growth of human glioblastoma cells

Détails

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Etat: Public
Version: Final published version
Licence: Tous droits réservés
ID Serval
serval:BIB_9F0C663201D6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Synthesis of new pyrrolidine derivatives as inhibitors of alpha-mannosidase and of the growth of human glioblastoma cells
Périodique
Heterocycles
Auteur⸱e⸱s
Favre S., Fiaux H., Schutz C., Vogel P., Juillerat-Jeanneret L., Gerber-Lemaire S.
ISSN
0385-5414
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
69
Numéro
1
Pages
179-192
Langue
anglais
Résumé
New 2-benzylamino-3,4-dihydroxypyrrolidines bearing aromatic and aliphatic amido side chains have been prepared. The influence of the amido substituents on the inhibitory activity of these diamines toward 24 commercially available glycosidases was determined. The most potent and selective a-mannosidase inhibitor (6d) (N-[(2R)-2-([(2R,3R,4S)-3,4-dihydroxypyrrolidin2-yl]methyl amino)-2-phenylethyl]-3-bromobenzamide) of these series was also the most potent inhibitor of the growth of human glioblastoma cells.
Mots-clé
alpha-Mannosidase/cancer cell death/glycoprotein processing/Golgi alpha-mannosidase II/selective glycosidase inhibitor/Cells/Glioblastoma/pyrrolidine derivatives
Web of science
Création de la notice
30/01/2008 19:10
Dernière modification de la notice
15/08/2020 6:19
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