Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex
Détails
ID Serval
serval:BIB_9EDF2200A133
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex
Périodique
Neuron
ISSN
0896-6273 (Print)
Statut éditorial
Publié
Date de publication
01/2003
Volume
37
Numéro
2
Pages
275-86
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Jan 23
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Jan 23
Résumé
Neuron-glia interactions are essential for synaptic function, and glial glutamate (re)uptake plays a key role at glutamatergic synapses. In knockout mice, for either glial glutamate transporters, GLAST or GLT-1, a classical metabolic response to synaptic activation (i.e., enhancement of glucose utilization) is decreased at an early functional stage in the somatosensory barrel cortex following activation of whiskers. Investigation in vitro demonstrates that glial glutamate transport represents a critical step for triggering enhanced glucose utilization, but also lactate release from astrocytes through a mechanism involving changes in intracellular Na(+) concentration. These data suggest that a metabolic crosstalk takes place between neurons and astrocytes in the developing cortex, which would be regulated by synaptic activity and mediated by glial glutamate transporters.
Mots-clé
Amino Acid Transport System X-AG/genetics/metabolism/*physiology
Animals
Animals, Newborn
Aspartic Acid/metabolism
Astrocytes/*physiology
Blotting, Western
Cells, Cultured
Cerebral Cortex/*growth & development/*physiology
Deoxyglucose/metabolism
Efferent Pathways/physiology
Excitatory Amino Acid Transporter 2/genetics/metabolism
Glycolysis/physiology
Immunohistochemistry
Lactic Acid/metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Neuroglia/*physiology
Neurons/*physiology
Physical Stimulation
Receptor Cross-Talk/*physiology
Somatosensory Cortex/physiology
Synapses/physiology
Vibrissae/innervation/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:40
Dernière modification de la notice
20/08/2019 15:05