Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex

Détails

ID Serval
serval:BIB_9EDF2200A133
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex
Périodique
Neuron
Auteur⸱e⸱s
Voutsinos-Porche  B., Bonvento  G., Tanaka  K., Steiner  P., Welker  E., Chatton  J. Y., Magistretti  P. J., Pellerin  L.
ISSN
0896-6273 (Print)
Statut éditorial
Publié
Date de publication
01/2003
Volume
37
Numéro
2
Pages
275-86
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Jan 23
Résumé
Neuron-glia interactions are essential for synaptic function, and glial glutamate (re)uptake plays a key role at glutamatergic synapses. In knockout mice, for either glial glutamate transporters, GLAST or GLT-1, a classical metabolic response to synaptic activation (i.e., enhancement of glucose utilization) is decreased at an early functional stage in the somatosensory barrel cortex following activation of whiskers. Investigation in vitro demonstrates that glial glutamate transport represents a critical step for triggering enhanced glucose utilization, but also lactate release from astrocytes through a mechanism involving changes in intracellular Na(+) concentration. These data suggest that a metabolic crosstalk takes place between neurons and astrocytes in the developing cortex, which would be regulated by synaptic activity and mediated by glial glutamate transporters.
Mots-clé
Amino Acid Transport System X-AG/genetics/metabolism/*physiology Animals Animals, Newborn Aspartic Acid/metabolism Astrocytes/*physiology Blotting, Western Cells, Cultured Cerebral Cortex/*growth & development/*physiology Deoxyglucose/metabolism Efferent Pathways/physiology Excitatory Amino Acid Transporter 2/genetics/metabolism Glycolysis/physiology Immunohistochemistry Lactic Acid/metabolism Mice Mice, Inbred C57BL Mice, Knockout Neuroglia/*physiology Neurons/*physiology Physical Stimulation Receptor Cross-Talk/*physiology Somatosensory Cortex/physiology Synapses/physiology Vibrissae/innervation/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:40
Dernière modification de la notice
20/08/2019 15:05
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