Role of peroxynitrite in the redox regulation of cell signal transduction pathways.

Détails

Ressource 1Télécharger: BIB_9EDAAC023D45.P001.pdf (1444.75 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_9EDAAC023D45
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Role of peroxynitrite in the redox regulation of cell signal transduction pathways.
Périodique
Frontiers in Bioscience
Auteur(s)
Liaudet Lucas, Vassalli Giuseppe, Pacher P.
ISSN
1093-4715[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
14
Pages
4809-4814
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review Publication Status: epublish
Résumé
Peroxynitrite is a potent oxidant and nitrating species formed from the reaction between the free radicals nitric oxide and superoxide. An excessive formation of peroxynitrite represents an important mechanism contributing to cell death and dysfunction in multiple cardiovascular pathologies, such as myocardial infarction, heart failure and atherosclerosis. Whereas initial works focused on direct oxidative biomolecular damage as the main route of peroxynitrite toxicity, more recent evidence, mainly obtained in vitro, indicates that peroxynitrite also behaves as a potent modulator of various cell signal transduction pathways. Due to its ability to nitrate tyrosine residues, peroxynitrite affects cellular processes dependent on tyrosine phosphorylation. Peroxynitrite also exerts complex effects on the activity of various kinases and phosphatases, resulting in the up- or downregulation of signalling cascades, in a concentration- and cell-dependent manner. Such roles of peroxynitrite in the redox regulation of key signalling pathways for cardiovascular homeostasis, including protein kinase B and C, the MAP kinases, Nuclear Factor Kappa B, as well as signalling dependent on insulin and the sympatho-adrenergic system are presented in detail in this review.
Mots-clé
Humans, Oxidation-Reduction, Peroxynitrous Acid/physiology, Signal Transduction/physiology
Pubmed
Web of science
Création de la notice
29/12/2009 11:19
Dernière modification de la notice
20/08/2019 16:05
Données d'usage