Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood.

Détails

ID Serval
serval:BIB_9ED287615ADA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Runne H., Kuhn A., Wild E.J., Pratyaksha W., Kristiansen M., Isaacs J.D., Régulier E., Delorenzi M., Tabrizi S.J., Luthi-Carter R.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
2007
Volume
104
Numéro
36
Pages
14424-14429
Langue
anglais
Résumé
Highly quantitative biomarkers of neurodegenerative disease remain an important need in the urgent quest for disease-modifying therapies. For Huntington's disease (HD), a genetic test is available (trait marker), but necessary state markers are still in development. In this report, we describe a large battery of transcriptomic tests explored as state biomarker candidates. In an attempt to exploit the known neuroinflammatory and transcriptional perturbations of disease, we measured relevant mRNAs in peripheral blood cells. The performance of these potential markers was weak overall, with only one mRNA, immediate early response 3 (IER3), showing a modest but significant increase of 32% in HD samples compared with controls. No statistically significant differences were found for any other mRNAs tested, including a panel of 12 RNA biomarkers identified in a previous report [Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HD, Hersch SM, Hogarth P, Bouzou B, Jensen RV, et al. (2005) Proc Natl Acad Sci USA 102:11023-11028]. The present results may nonetheless inform the future design and testing of HD biomarker strategies.
Mots-clé
Biological Markers/blood, Gene Expression Regulation, Humans, Huntington Disease/blood, Huntington Disease/genetics, Intracellular Membranes/metabolism, Lymphocytes/metabolism, Oligonucleotide Array Sequence Analysis, RNA/genetics, Transcription, Genetic/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/04/2013 8:10
Dernière modification de la notice
20/08/2019 15:05
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