The African Great Lakes Region has experienced substantial land use land cover change (LULCC) over the last decades, driven by a complex interplay of various factors. However, a comprehensive analysis exploring the relationships between LULCC, and its explanatory variables remains unexplored. This study focused on the Lake Kivu catchment in Rwanda, analysing LULCC from 1990 to 2020, identifying major variables, and predicting future LULC scenarios under different development trajectories. Image classification was conducted in Google Earth Engine using random forest classifier, by incorporating seasonal composites Landsat images, spectral indices, and topographic features, to enhance discrimination and capture seasonal variations. The results demonstrated an overall accuracy exceeding 83%. Historical analysis revealed significant changes, including forest loss (26.6 to 18.7%) and agricultural land expansion (27.7 to 43%) in the 1990–2000 decade, attributed to political conflicts and population movements. Forest recovery (24.8% by 2020) was observed in subsequent decades, driven by Rwanda’s sustainable development initiatives. A Multi-Layer Perceptron neural network from Land Change Modeler predicted distinct 2030 and 2050 LULC scenarios based on natural, socio-economic variables, and historical transitions. Analysis of explanatory variables highlighted the significant role of proximity to urban centers, population density, and terrain in LULCC. Predictions indicate distinct trajectories influenced by demographic and socio-economic trends. The study recommends adopting the Green Growth Economy scenario aligned with ongoing conservation measures. The findings contribute to identifying opportunities for land restoration and conservation efforts, promoting the preservation of Lake Kivu catchment’s ecological integrity, in alignment with national and global goals.