Monoclonal gammopathy in a 30 weeks old premature infant

Détails

ID Serval
serval:BIB_9DFE68D447FA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Monoclonal gammopathy in a 30 weeks old premature infant
Périodique
Applied and Theoretical Electrophoresis
Auteur⸱e⸱s
Tissot  J. D., Schneider  P., Hohlfeld  P., Tolsa  J. F., Calame  A., Hochstrasser  D. F.
ISSN
0954-6642 (Print)
Statut éditorial
Publié
Date de publication
1992
Volume
3
Numéro
2
Pages
67-8
Notes
Case Reports
Journal Article
Résumé
The occurrence of monoclonal gammopathy in childhood is extremely rare. This report describes the presence of a monoclonal immunoglobulin in a 30 week old premature infant, incidentally discovered by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) during an ongoing study of the plasma/serum protein development. Comparative analysis of the electrophoretogram of the infant with 'reference' protein maps revealed the presence of an 'abnormal' immunoglobulin light chain spot. A spot having an identical apparent molecular weight and isoelectric point was also detected after 2D-PAGE of the mother's plasma and its Protein-A purified immunoglobulin fraction. The observation of a monoclonal gammopathy in a premature infant, most likely transmitted from his mother, highlights the potential usefulness of 2D-PAGE in the clinical laboratory.
Mots-clé
Blood Protein Electrophoresis Electrophoresis, Gel, Two-Dimensional Female Humans Immunoglobulin lambda-Chains/*blood Infant, Newborn *Infant, Premature Male Maternal-Fetal Exchange *Paraproteinemias/blood Paraproteins/*analysis Pregnancy Puerperal Disorders/*blood
Pubmed
Création de la notice
25/01/2008 15:34
Dernière modification de la notice
20/08/2019 15:04
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