Systemic antibodies can inhibit mouse mammary tumor virus-driven superantigen response in mucosa-associated lymphoid tissues.
Détails
ID Serval
serval:BIB_9DFB88E54072
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Systemic antibodies can inhibit mouse mammary tumor virus-driven superantigen response in mucosa-associated lymphoid tissues.
Périodique
Journal of Virology
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
73
Numéro
2
Pages
1729-1733
Langue
anglais
Résumé
Many mucosal pathogens invade the host by initially infecting the organized mucosa-associated lymphoid tissue (o-MALT) such as Peyer's patches or nasal cavity-associated lymphoid tissue (NALT) before spreading systemically. There is no clear demonstration that serum antibodies can prevent infections in o-MALT. We have tested this possibility by using the mouse mammary tumor virus (MMTV) as a model system. In peripheral lymph nodes or in Peyer's patches or NALT, MMTV initially infects B lymphocytes, which as a consequence express a superantigen (SAg) activity. The SAg molecule induces the local activation of a subset of T cells within 6 days after MMTV infection. We report that similar levels of anti-SAg antibody (immunoglobulin G) in serum were potent inhibitors of the SAg-induced T-cell response both in peripheral lymph nodes and in Peyer's patches or NALT. This result clearly demonstrates that systemic antibodies can gain access to Peyer's patches or NALT.
Mots-clé
Animals, Antibodies, Viral/immunology, Antigens, Viral/immunology, Immunity, Mucosal, Immunoglobulin G/immunology, Lymphoid Tissue/immunology, Mammary Tumor Virus, Mouse/immunology, Mice, Mucous Membrane/immunology, Superantigens/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 14:48
Dernière modification de la notice
20/08/2019 15:04