Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes.

Détails

ID Serval
serval:BIB_9DE12A6FA869
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes.
Périodique
Structure
Auteur⸱e⸱s
Palecek J.J., Gruber S.
ISSN
1878-4186 (Electronic)
ISSN-L
0969-2126
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
23
Numéro
12
Pages
2183-2190
Langue
anglais
Résumé
SMC/kleisin complexes form elongated annular structures, which are critical for chromosome segregation, genome maintenance, and the regulation of gene expression. We describe marked structural similarities between bacterial and eukaryotic SMC/kleisin partner proteins (designated here as "kite" proteins for kleisin interacting tandem winged-helix (WH) elements of SMC complexes). Kite proteins are integral parts of all prokaryotic SMC complexes and Smc5/6 but not cohesin and condensin. They are made up of tandem WH domains, form homo- or heterodimers via their amino-terminal WH domain, and they associate with the central part of a kleisin subunit. In placental mammals, the kite subunit NSE3 gave rise to several (>60) kite-related proteins, named MAGE, many of which encode tumor- and testis-specific antigens. Based on architectural rather than sequence similarity, we propose an adapted model for the evolution of the SMC protein complexes and discuss potential functional similarities between bacterial Smc/ScpAB and eukaryotic Smc5/6.
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/08/2016 10:46
Dernière modification de la notice
20/08/2019 16:04
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