FOXC2 and NFATc1 control formation and maturation of collecting lymphatic vessels

Détails

ID Serval
serval:BIB_9DD0E37BF60A
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
FOXC2 and NFATc1 control formation and maturation of collecting lymphatic vessels
Titre de la conférence
Joint Meeting of the Society for Microcirculation and Vascular Biology Swiss Society for Microcirculation
Auteur⸱e⸱s
Norrmen C., Ivanov K. I., Cheng J., Zangger N., Delorenzi M., Jaquet M., Miura N., Puolakkainen P., Horsley V., Hu J., Augustin H. G., Yla-Herttuala S., Alitalo K., Petrova T. V.
Adresse
Bern, Switzerland, Oct 08, 2009
ISBN
1018-1172
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
46
Série
Journal of Vascular Research
Pages
45-45
Langue
anglais
Notes
Meeting Abstract
Résumé
The mechanisms of blood vessel maturation into distinct parts of the blood vasculature such as arteries, veins, and capillaries have been the subject of intense investigation over recent years. In contrast, our knowledge of lymphatic vessel maturation is still fragmentary. In this study, we provide a molecular and morphological characterization of the major steps in the maturation of the primary lymphatic capillary plexus into collecting lymphatic vessels during development and show that forkhead transcription factor Foxc2 controls this process. We further identify transcription factor NFATc1 as a novel regulator of lymphatic development and describe a previously unsuspected link between NFATc1 and Foxc2 in the regulation of lymphatic maturation. We also provide a genome-wide map of FOXC2-binding sites in lymphatic endothelial cells, identify a novel consensus FOXC2 sequence, and show that NFATc1 physically interacts with FOXC2-binding enhancers. These data provide novel insights into the molecular program of lymphatic vascular specification and suggest that FOXC2 and NFATc1 are potential targets for therapeutic intervention.
Web of science
Création de la notice
27/10/2009 16:37
Dernière modification de la notice
20/08/2019 15:04
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