Arsenic-contaminated drinking water and cholangiocarcinoma.

Détails

ID Serval
serval:BIB_9DB9061C9152
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Arsenic-contaminated drinking water and cholangiocarcinoma.
Périodique
European journal of cancer prevention
Auteur⸱e⸱s
Reyes D., Ganesan N., Boffetta P., Labgaa I.
ISSN
1473-5709 (Electronic)
ISSN-L
0959-8278
Statut éditorial
Publié
Date de publication
01/01/2023
Peer-reviewed
Oui
Volume
32
Numéro
1
Pages
10-17
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Cholangiocarcinoma (CCA) is an aggressive tumor occurring in bile ducts and associated with dismal outcomes. It can be classified according to anatomical location as intrahepatic cholangiocarcinoma (ICC) or extrahepatic cholangiocarcinoma (ECC). Although some risk factors have been identified, our understanding of these tumors remains limited. Arsenic (As) is a prevalent toxicant with established associations with bladder, skin and lung cancers while pilot data on its potential carcinogenic role on digestive tumors are emerging. This ecological study aimed to investigate the association between exposure to As-contaminated drinking water and CCA.
Analyses were conducted for the US, Taiwan and India due to the quality of publicly available datasets including small area-level information. Statistics included coefficient correlations analyses as well as univariate and multivariate linear regressions.
In the US, no correlation was observed between As and CCA. In Taiwan, correlations were identified for ICC in men (Spearman = 0.55, P = 0.01) and women (Spearman = 0.67, P < 0.01), as well as for ECC in men (Spearman = 0.62, P < 0.01). In India, counties with As level of at least 50 µg/L showed higher incidences of ECC in men ( R2 = 0.26, P = 0.01) and women ( R2 = 0.31, P < 0.01).
These findings highlighted a potential carcinogenic impact of As in drinking water on bile duct cancers, paving the way for future studies aiming to replicate this association with individual data as well as its clinical and ecological implications.
Mots-clé
Male, Female, Humans, Bile Ducts, Intrahepatic/pathology, Drinking Water/adverse effects, Bile Ducts, Extrahepatic/pathology, Arsenic/toxicity, Cholangiocarcinoma/chemically induced, Cholangiocarcinoma/epidemiology, Bile Duct Neoplasms/chemically induced, Bile Duct Neoplasms/epidemiology
Pubmed
Web of science
Création de la notice
24/01/2022 19:26
Dernière modification de la notice
17/10/2023 6:13
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