Myocardial salvage through coronary collateral growth by granulocyte colony-stimulating factor in chronic coronary artery disease: a controlled randomized trial.

Détails

ID Serval
serval:BIB_9D976EB00501
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Myocardial salvage through coronary collateral growth by granulocyte colony-stimulating factor in chronic coronary artery disease: a controlled randomized trial.
Périodique
Circulation
Auteur⸱e⸱s
Meier P., Gloekler S., de Marchi S.F., Indermuehle A., Rutz T., Traupe T., Steck H., Vogel R., Seiler C.
ISSN
1524-4539 (Electronic)
ISSN-L
0009-7322
Statut éditorial
Publié
Date de publication
06/10/2009
Peer-reviewed
Oui
Volume
120
Numéro
14
Pages
1355-1363
Langue
anglais
Notes
Publication types: Controlled Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The efficacy of granulocyte colony-stimulating factor (G-CSF) for coronary collateral growth promotion and thus impending myocardial salvage has not been studied so far, to our best knowledge.
In 52 patients with chronic stable coronary artery disease, age 62+/-11 years, the effect on a marker of myocardial infarct size (ECG ST segment elevation) and on quantitative collateral function during a 1-minute coronary balloon occlusion was tested in a randomized, placebo-controlled, double-blind fashion. The study protocol before coronary intervention consisted of occlusive surface and intracoronary lead ECG recording as well as collateral flow index (CFI, no unit) measurement in a stenotic and a > or =1 normal coronary artery before and after a 2-week period with subcutaneous G-CSF (10 microg/kg; n=26) or placebo (n=26). The CFI was determined by simultaneous measurement of mean aortic, distal coronary occlusive, and central venous pressure. The ECG ST segment elevation >0.1 mV disappeared significantly more often in response to G-CSF (11/53 vessels; 21%) than to placebo (0/55 vessels; P=0.0005), and simultaneously, CFI changed from 0.121+/-0.087 at baseline to 0.166+/-0.086 at follow-up in the G-CSF group, and from 0.152+/-0.082 to 0.131+/-0.071 in the placebo group (P<0.0001 for interaction of treatment and time). The absolute change in CFI from baseline to follow-up amounted to +0.049+/-0.062 in the G-CSF group and to -0.010+/-0.060 in the placebo group (P<0.0001).
Subcutaneous G-CSF is efficacious during a short-term protocol in improving signs of myocardial salvage by coronary collateral growth promotion.

Mots-clé
Aged, Angina Pectoris/physiopathology, Angioplasty, Balloon, Coronary, Cardiac Catheterization, Cardiovascular Diseases/epidemiology, Chest Pain/epidemiology, Chronic Disease, Coronary Angiography, Coronary Artery Disease/drug therapy, Double-Blind Method, Echocardiography, Female, Granulocyte Colony-Stimulating Factor/therapeutic use, Humans, Hyperemia, Male, Middle Aged, Myocardial Infarction/epidemiology, Myocardial Ischemia/physiopathology, Placebos, Risk Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/08/2017 11:23
Dernière modification de la notice
20/08/2019 15:03
Données d'usage