Whole-genome sequencing analysis of semi-supercentenarians.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_9D4703EE2910
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Whole-genome sequencing analysis of semi-supercentenarians.
Périodique
eLife
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Statut éditorial
Publié
Date de publication
04/05/2021
Peer-reviewed
Oui
Volume
10
Pages
e57849
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme decades of human life avoided or largely postponed all major age-related diseases. In this study, we sequenced at high coverage (90X) the whole genome of 81 semi-supercentenarians and supercentenarians [105+/110+] (mean age: 106.6 ± 1.6) and of 36 healthy unrelated geographically matched controls (mean age 68.0 ± 5.9) recruited in Italy. The results showed that 105+/110+ are characterized by a peculiar genetic background associated with efficient DNA repair mechanisms, as evidenced by both germline data (common and rare variants) and somatic mutations patterns (lower mutation load if compared to younger healthy controls). Results were replicated in a second independent cohort of 333 Italian centenarians and 358 geographically matched controls. The genetics of 105+/110+ identified DNA repair and clonal haematopoiesis as crucial players for healthy aging and for the protection from cardiovascular events.
Mots-clé
ageing, clonal hematopoiesis, genetics, genomics, geroscience, human, longevity, semi-supercentenarians, sequencing
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/05/2021 17:16
Dernière modification de la notice
12/01/2022 8:12