Lateral elbow pain syndrome in adults is a frequent complaint leading to consultation in primary care medicine. The lateral side of the elbow joint represents a complex anatomy with close proximity of bony structures (humerus, radius, and ulna), ligaments (lateral ligament complex), tendons (origin of the extensors of the wrist and fingers), and nerves (branches of the radial nerve) making diagnostic and therapeutic management demanding. This article aims to provide a basis for reflection to better define treatment options for pathologies frequently encountered in clinical practice.