Changes in tissues and organs through PMCTA carrier substances.

Détails

ID Serval
serval:BIB_9C740044BFE5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Changes in tissues and organs through PMCTA carrier substances.
Périodique
International journal of legal medicine
Auteur⸱e⸱s
Bruch G.M., Feldmann NHC, Fischer F.T., Fracasso T., Grabherr S., Genet P.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
In Press
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Résumé
To date, lipophilic contrast agents mixed with oil, usually paraffin oil, are the most commonly used contrast agents in post-mortem computed tomography angiography (PMCTA). Iodine-based hydrophilic contrast media in combination with a water-soluble carrier, e.g. polyethylene glycol (PEG), are also common. However, their influence on different tissues and organs is poorly understood. In order to analyse the changes in the cadavers caused by the different carrier substances, we evaluated the effects of PEG 200 and oil on the different tissues and organs. Therefore, during a forensic autopsy, liquid femoral vein blood and samples of different organs and vessels were taken and preserved at room temperature in the two liquids mentioned. The condition of the samples was documented during the autopsy and 24, 48 and 72 h after preservation. Microscopic examination took place after 72 h. After 24 h, the samples placed in PEG 200 already showed a clear solidification of almost all structures. Crumbly blood agglomerates had formed in the previously liquid blood. In contrast, the samples stored in oil showed signs of classic cadaveric decomposition after 24 h, which increased with time. The microscopic and immunohistochemical evaluation of the samples stored in PEG showed a good diagnostic quality. The analysis of tissues stored in oil was much more difficult due to putrefaction. PEG and oil show significantly different effects on human tissues, mainly conservation and dehydration are affected. It is crucial to be aware of these differences in order to choose the most appropriate PMCTA method for each forensic case.
Mots-clé
Carrier substance, PEG, PMCTA, Paraffin oil, Polyethylenglycole
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/10/2024 12:57
Dernière modification de la notice
20/12/2024 7:07
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