A Cellular Perspective on Brain Energy Metabolism and Functional Imaging.

Détails

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Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_9C72046E95F9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A Cellular Perspective on Brain Energy Metabolism and Functional Imaging.
Périodique
Neuron
Auteur⸱e⸱s
Magistretti P.J., Allaman I.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
86
Numéro
4
Pages
883-901
Langue
anglais
Notes
Publication types: <Publication Status: ppublish
Résumé
The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expression of energy metabolism genes. Functional brain imaging techniques such as fMRI and PET, which are widely used in human neuroscience studies, detect signals that monitor energy delivery and use in register with neuronal activity. Recent technological advances in metabolic studies with cellular resolution have afforded decisive insights into the understanding of the cellular and molecular bases of the coupling between neuronal activity and energy metabolism and point at a key role of neuron-astrocyte metabolic interactions. This article reviews some of the most salient features emerging from recent studies and aims at providing an integration of brain energy metabolism across resolution scales.
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/05/2015 8:57
Dernière modification de la notice
16/02/2021 7:27
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