Endocrine causes of nonalcoholic fatty liver disease.

Détails

ID Serval
serval:BIB_9C084B4D0CBF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Endocrine causes of nonalcoholic fatty liver disease.
Périodique
World Journal of Gastroenterology
Auteur⸱e⸱s
Marino L., Jornayvaz F.R.
ISSN
2219-2840 (Electronic)
ISSN-L
1007-9327
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
21
Numéro
39
Pages
11053-11076
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the industrialized world. The prevalence of NAFLD is increasing, becoming a substantial public health burden. NAFLD includes a broad spectrum of disorders, from simple conditions such as steatosis to severe manifestations such as fibrosis and cirrhosis. The relationship of NAFLD with metabolic alterations such as type 2 diabetes is well described and related to insulin resistance, with NAFLD being recognized as the hepatic manifestation of metabolic syndrome. However, NAFLD may also coincide with endocrine diseases such as polycystic ovary syndrome, hypothyroidism, growth hormone deficiency or hypercortisolism. It is therefore essential to remember, when discovering altered liver enzymes or hepatic steatosis on radiological exams, that endocrine diseases can cause NAFLD. Indeed, the overall prognosis of NAFLD may be modified by treatment of the underlying endocrine pathology. In this review, we will discuss endocrine diseases that can cause NALFD. Underlying pathophysiological mechanisms will be presented and specific treatments will be reviewed.
Mots-clé
Endocrine diseases, Nonalcoholic fatty liver disease, Insulin resistance, Obesity, Type 2 diabetes
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/11/2015 18:27
Dernière modification de la notice
20/08/2019 16:02
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