FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression.
Détails
ID Serval
serval:BIB_9C02BE4B6FF2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression.
Périodique
Movement Disorders
ISSN
1531-8257[electronic], 0885-3185[linking]
Statut éditorial
Publié
Date de publication
2009
Volume
24
Numéro
3
Pages
455-459
Langue
anglais
Résumé
Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and alpha-synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient-control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and alpha-synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and alpha-synuclein protein levels.
Mots-clé
Adult, Aged, Aged, 80 and over, Female, Fibroblast Growth Factors/genetics, Humans, Male, Middle Aged, Parkinson Disease/genetics, alpha-Synuclein/genetics
Pubmed
Création de la notice
24/09/2010 19:39
Dernière modification de la notice
20/08/2019 16:02